OK so IST-3 is out. It’s a big and important trial so make sure and read it. Stroke lytics get a lot of attention from EM folks, if only because we seem the only ones not convinced of its efficacy. … Read More »
Parsons M, Spratt N, Bivard A, Campbell B, Chung K, Miteff F, et al. A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med. 2012 Mar. 22;366(12):1099–1107. PMID 22435369 See Ryan’s review of this paper published … Read More »
If you’ve read the sprawling behemoth that is my critique of (now not so) recent stroke literature you’ll notice that it ends with a spiel on IST-3 – the big 3000 pt RCT that hopes to settle the question of … Read More »
The always excellent Emergency Medicine Literature of Note had a great post on stroke mimics and what happens when they get tPA. It was a study trying to say that only 1.4% of their tPA patients were stroke mimics but … Read More »
Only a quickie this time. I mentioned in the first part that I wasn’t planning to discuss the details of the MAST trials as they used streptokinase as the agent and this is no longer used. In short both trials … Read More »